| 1. Jornada | 25.07.2021 | KV Mechelen | - | Royal Antwerp FC | 3:2 | ||||
| 4. Jornada | 15.08.2021 | Gante | - | KV Mechelen | 2:0 |  |
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| 5. Jornada | 22.08.2021 | KV Mechelen | - | Union Saint-Gilloise | 3:1 | ||||
| 6. Jornada | 27.08.2021 | KV Kortrijk | - | KV Mechelen | 2:2 | ||||
| 7. Jornada | 12.09.2021 | RSC Anderlecht | - | KV Mechelen | 7:2 | ||||
| 8. Jornada | 18.09.2021 | KV Mechelen | - | Oud-Heverlee Leuven | 2:0 | |
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| 9. Jornada | 26.09.2021 | Sporting Charleroi | - | KV Mechelen | 0:2 | ||||
| 10. Jornada | 01.10.2021 | KV Mechelen | - | Standard Liège | 3:1 | ||||
| 11. Jornada | 17.10.2021 | K Beerschot VA | - | KV Mechelen | 0:1 | ||||
| 12. Jornada | 23.10.2021 | KV Mechelen | - | SV Zulte Waregem | 2:2 | ||||
| 13. Jornada | 29.10.2021 | KV Oostende | - | KV Mechelen | 2:4 | |
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| 14. Jornada | 06.11.2021 | KV Mechelen | - | Sint-Truidense VV | 0:1 | ||||
| 15. Jornada | 19.11.2021 | KV Mechelen | - | Club Brugge KV | 2:1 | ||||
| 16. Jornada | 27.11.2021 | Cercle Brugge | - | KV Mechelen | 3:1 | ||||
| 17. Jornada | 05.12.2021 | KV Mechelen | - | KRC Genk | 1:1 | ||||
| 20. Jornada | 18.12.2021 | SV Zulte Waregem | - | KV Mechelen | 3:2 | ||||
| 21. Jornada | 27.12.2021 | KV Mechelen | - | RFC Seraing | 2:0 | |
Trinidad y Tobago
