| 7. Jornada | 11.09.2021 | USL Dunkerque | - | AS Nancy Lorraine | 0:0 |  |
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| 8. Jornada | 18.09.2021 | AS Nancy Lorraine | - | Havre AC | 1:1 | ||||
| 9. Jornada | 21.09.2021 | Grenoble Foot 38 | - | AS Nancy Lorraine | 4:1 | ||||
| 11. Jornada | 02.10.2021 | Paris FC | - | AS Nancy Lorraine | 1:1 | ||||
| 12. Jornada | 16.10.2021 | AS Nancy Lorraine | - | Guingamp | 2:1 | |
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| 13. Jornada | 23.10.2021 | AC Ajaccio | - | AS Nancy Lorraine | 2:0 | ||||
| 14. Jornada | 30.10.2021 | AS Nancy Lorraine | - | FC Sochaux | 0:0 | ||||
| 15. Jornada | 06.11.2021 | Chamois Niortais | - | AS Nancy Lorraine | 1:3 | ||||
| 16. Jornada | 20.11.2021 | AS Nancy Lorraine | - | Rodez AF | 0:2 | ||||
| 17. Jornada | 03.12.2021 | US Quevilly-Rouen | - | AS Nancy Lorraine | 2:1 | ||||
| 18. Jornada | 11.12.2021 | Nîmes Olympique | - | AS Nancy Lorraine | 2:1 | ||||
| 19. Jornada | 21.12.2021 | AS Nancy Lorraine | - | Dijon FCO | 0:3 | ||||
| 21. Jornada | 15.01.2022 | AS Nancy Lorraine | - | Bastia | 2:1 | |
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| 20. Jornada | 19.01.2022 | Toulouse | - | AS Nancy Lorraine | 4:0 | ||||
| 22. Jornada | 01.02.2022 | Valenciennes FC | - | AS Nancy Lorraine | 6:1 | ||||
| 23. Jornada | 05.02.2022 | AS Nancy Lorraine | - | Caen | 1:1 | ||||
| 38. Jornada | 14.05.2022 | AS Nancy Lorraine | - | Pau FC | 2:3 |
Bélgica