| 5. Jornada | 06.08.2021 | Unión de Santa Fe II | - | San Lorenzo II | 1:1 | ||||
| 6. Jornada | 13.08.2021 | Talleres de Córdoba II | - | San Lorenzo II | 1:0 | ||||
| 9. Jornada | 30.08.2021 | San Lorenzo II | - | Patronato de Paraná II | 2:2 | ||||
| 12. Jornada | 17.09.2021 | Rosario Central II | - | San Lorenzo II | 1:2 |  |
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| 13. Jornada | 24.09.2021 | San Lorenzo II | - | Defensa y Justicia II | 0:2 | ||||
| 14. Jornada | 01.10.2021 | Atlético Tucumán II | - | San Lorenzo II | 1:1 | ||||
| 16. Jornada | 15.10.2021 | River Plate II | - | San Lorenzo II | 1:3 | ||||
| 17. Jornada | 18.10.2021 | San Lorenzo II | - | Lanús II | 0:0 | ||||
| 18. Jornada | 22.10.2021 | Huracán II | - | San Lorenzo II | 0:1 | ||||
| 19. Jornada | 31.10.2021 | San Lorenzo II | - | Godoy Cruz II | 0:1 | ||||
| 20. Jornada | 05.11.2021 | Vélez Sarsfield II | - | San Lorenzo II | 2:0 | ||||
| 21. Jornada | 18.11.2021 | San Lorenzo II | - | Gimnasia de La Plata II | 4:1 | ||||
| 22. Jornada | 23.11.2021 | Aldosivi II | - | San Lorenzo II | 1:0 | ||||
| 23. Jornada | 27.11.2021 | San Lorenzo II | - | Sarmiento de Junín II | 3:1 | ||||
| 24. Jornada | 06.12.2021 | Independiente II | - | San Lorenzo II | 1:0 | ||||
| 25. Jornada | 10.12.2021 | San Lorenzo II | - | Newell's Old Boys II | 2:1 |
Argentina