| 1. Jornada | 09.01.2022 | Santos Laguna [Sub 16] | - | CF Monterrey [Sub 16] | 0:0 | ||||
| 4. Jornada | 29.01.2022 | Santos Laguna [Sub 16] | - | Deportivo Guadalajara [Sub 16] | 0:1 | ||||
| 5. Jornada | 04.02.2022 | Atlético San Luis [Sub 16] | - | Santos Laguna [Sub 16] | 2:1 | ||||
| 11. Jornada | 19.03.2022 | Santos Laguna [Sub 16] | - | Atlético San Luis [Sub 16] | 2:1 | ||||
| 12. Jornada | 26.03.2022 | Santos Laguna [Sub 16] | - | Mazatlán FC [Sub 16] | 3:1 | ||||
| 15. Jornada | 20.04.2022 | Club Tijuana [Sub 16] | - | Santos Laguna [Sub 16] | 0:1 |  |
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| 16. Jornada | 23.04.2022 | Santos Laguna [Sub 16] | - | UANL Tigres [Sub 16] | 5:0 | ||||
| 18. Jornada | 07.05.2022 | Santos Laguna [Sub 16] | - | Club León [Sub 16] | 2:1 |
México