| 2. Jornada | 18.07.2010 | Metalurg Zaporizhya | - | Shakhtar Donetsk | 1:1 | ||||
| 4. Jornada | 30.07.2010 | Arsenal Kiev | - | Shakhtar Donetsk | 1:3 | ||||
| 6. Jornada | 15.08.2010 | Shakhtar Donetsk | - | Karpaty Lviv | 1:0 | ||||
| 8. Jornada | 29.08.2010 | Shakhtar Donetsk | - | FK Illichivets | 1:0 |  |
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| 9. Jornada | 10.09.2010 | FK Obolon | - | Shakhtar Donetsk | 1:0 | ||||
| 10. Jornada | 19.09.2010 | Shakhtar Donetsk | - | Tavriya Simferopol (1958-2014) | 4:1 | ||||
| 12. Jornada | 03.10.2010 | Shakhtar Donetsk | - | Dinamo Kiev | 2:0 | ||||
| 14. Jornada | 23.10.2010 | Shakhtar Donetsk | - | Vorskla Poltava | 1:0 | ||||
| 15. Jornada | 30.10.2010 | Dnipro Dnipropetrovsk | - | Shakhtar Donetsk | 0:1 | |
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| 16. Jornada | 06.11.2010 | FK Krivbas (old) | - | Shakhtar Donetsk | 0:2 | |
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| 17. Jornada | 13.11.2010 | Shakhtar Donetsk | - | Metalurg Zaporizhya | 2:1 | ||||
| 20. Jornada | 03.03.2011 | PFK Sevastopol | - | Shakhtar Donetsk | 0:1 | ||||
| 21. Jornada | 13.03.2011 | Karpaty Lviv | - | Shakhtar Donetsk | 1:0 | |
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| 27. Jornada | 01.05.2011 | Dinamo Kiev | - | Shakhtar Donetsk | 3:0 | ||||
| 29. Jornada | 14.05.2011 | Vorskla Poltava | - | Shakhtar Donetsk | 1:1 | |
Ucrania
