| 1. Jornada | 21.08.2021 | RSC Anderlecht [Sub 18] | - | KV Mechelen [Sub 18] | 2:1 | ||||
| 2. Jornada | 28.08.2021 | KV Mechelen [Sub 18] | - | Sint-Truidense VV [Sub 18] | 3:3 |  |
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| 4. Jornada | 11.09.2021 | KAA Gent [Sub 18] | - | KV Mechelen [Sub 18] | 1:3 | ||||
| 6. Jornada | 25.09.2021 | Sporting Charleroi [Sub 18] | - | KV Mechelen [Sub 18] | 2:1 | |
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| 7. Jornada | 02.10.2021 | KV Mechelen [Sub 18] | - | KRC Genk [Sub 18] | 2:3 | ||||
| 8. Jornada | 09.10.2021 | SV Zulte Waregem [Sub 18] | - | KV Mechelen [Sub 18] | 3:1 | |
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| 3. Jornada | 27.10.2021 | Club Brugge KV [Sub 18] | - | KV Mechelen [Sub 18] | 8:0 | ||||
| 11. Jornada | 06.11.2021 | KV Mechelen [Sub 18] | - | Cercle Brugge [Sub 18] | 7:1 | |
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| 13. Jornada | 20.11.2021 | KV Mechelen [Sub 18] | - | Oud-Heverlee Leuven [Sub 18] | 2:1 | |
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| 17. Jornada | 29.01.2022 | KV Mechelen [Sub 18] | - | Sporting Charleroi [Sub 18] | 0:2 | ||||
| 12. Jornada | 26.02.2022 | Standard Liège [Sub 18] | - | KV Mechelen [Sub 18] | 1:1 |
Bélgica