| 3. Jornada | 07.08.2021 | Zenit | - | FK Krasnodar | 3:2 |  |
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| 7. Jornada | 13.09.2021 | FK Rostov | - | FK Krasnodar | 1:1 | ||||
| 8. Jornada | 18.09.2021 | Akhmat Grozny | - | FK Krasnodar | 0:2 | ||||
| 9. Jornada | 26.09.2021 | FK Krasnodar | - | FK Sochi | 3:0 |  |
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| 11. Jornada | 17.10.2021 | FK Krasnodar | - | FK Ufa | 1:1 |  |
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| 14. Jornada | 06.11.2021 | Dinamo Moskva | - | FK Krasnodar | 1:0 | ||||
| 15. Jornada | 20.11.2021 | FK Krasnodar | - | Spartak Moskva | 2:1 | ||||
| 16. Jornada | 27.11.2021 | FK Khimki | - | FK Krasnodar | 3:3 | ||||
| 17. Jornada | 05.12.2021 | FK Sochi | - | FK Krasnodar | 1:2 | ||||
| 18. Jornada | 12.12.2021 | FK Krasnodar | - | FK Nizhny Novgorod | 0:0 |
Serbia