| 13. Jornada | 16.10.2021 | Atlético San Luis [Sub 20] | - | CF América [Sub 20] | 1:0 |  |
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| 15. Jornada | 24.10.2021 | Atlético San Luis [Sub 20] | - | Atlas Guadalajara [Sub 20] | 0:2 | ||||
| 16. Jornada | 31.10.2021 | Atlético San Luis [Sub 20] | - | CF Monterrey [Sub 20] | 3:1 | |
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| 5. Jornada | 03.11.2021 | CF Pachuca [Sub 20] | - | Atlético San Luis [Sub 20] | 1:3 |  |
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| 17. Jornada | 07.11.2021 | Santos Laguna [Sub 20] | - | Atlético San Luis [Sub 20] | 2:1 |  |
México