 |
 |
|
|
| 14.10.2021 | 16:00 | Gallos Blancos | - | Club Tijuana | 3:3 (1:1) | |
| 15.10.2021 | 16:00 | Club Necaxa | - | Puebla FC | 1:1 (0:1) | |
| 17:00 | Mazatlán FC | - | Atlas Guadalajara | 3:1 (3:1) | ||
| 16.10.2021 | 16:00 | Cruz Azul | - | UANL Tigres | 1:0 (1:0) | |
| 16:00 | CF Monterrey | - | Club León | 1:1 (1:0) | ||
| 16:00 | Atlético San Luis | - | CF América | 1:0 (0:0) | ||
| 19:00 | CF Pachuca | - | Santos Laguna | 2:2 (1:0) | ||
| 17.10.2021 | 16:00 | Pumas UNAM | - | FC Juárez | 3:0 (0:0) | |
| 16:00 | Deportivo Guadalajara | - | Deportivo Toluca | 4:1 (2:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Toluca | 13 | 7 | 2 | 4 | 20:15 | 5 | 23 |
| 2 |
|
Santos Laguna | 13 | 6 | 4 | 3 | 27:20 | 7 | 22 |
| 3 |
|
Cruz Azul | 13 | 5 | 6 | 2 | 11:7 | 4 | 21 |
| 4 |
|
Club León | 13 | 6 | 3 | 4 | 15:13 | 2 | 21 |
| 5 |
|
CF América | 13 | 5 | 5 | 3 | 20:16 | 4 | 20 |
| 6 |
|
Deportivo Guadalajara | 13 | 6 | 2 | 5 | 20:20 | 0 | 20 |
| 7 |
|
Atlas Guadalajara | 13 | 6 | 2 | 5 | 19:19 | 0 | 20 |
| 8 |
|
Mazatlán FC | 13 | 5 | 3 | 5 | 24:27 | -3 | 18 |
| 9 |
|
Club Necaxa | 13 | 4 | 5 | 4 | 21:19 | 2 | 17 |
| 10 |
|
UANL Tigres | 13 | 5 | 2 | 6 | 17:16 | 1 | 17 |
| 11 |
|
Atlético San Luis | 13 | 5 | 2 | 6 | 21:21 | 0 | 17 |
|
Club Tijuana | 13 | 4 | 5 | 4 | 21:21 | 0 | 17 | |
| 13 |
|
CF Pachuca | 13 | 3 | 7 | 3 | 15:15 | 0 | 16 |
| 14 |
|
Gallos Blancos | 13 | 4 | 4 | 5 | 17:18 | -1 | 16 |
| 15 |
|
CF Monterrey | 13 | 4 | 3 | 6 | 18:18 | 0 | 15 |
| 16 |
|
Pumas UNAM | 13 | 4 | 3 | 6 | 20:23 | -3 | 15 |
| 17 |
|
Puebla FC | 13 | 3 | 6 | 4 | 21:25 | -4 | 15 |
| 18 |
|
FC Juárez | 13 | 1 | 4 | 8 | 9:23 | -14 | 7 |
| Playoff |
