 |
 |
|
|
| 15.09.2021 | 16:00 | CF América | - | Santos Laguna | 0:1 (0:1) | |
| 21.09.2021 | 17:00 | FC Juárez | - | Atlético San Luis | 1:2 (1:1) | |
| 19.10.2021 | 16:00 | Atlas Guadalajara | - | Cruz Azul | 0:0 (0:0) | |
| 16:00 | Gallos Blancos | - | CF Monterrey | 1:1 (1:0) | ||
| 16:00 | Puebla FC | - | Mazatlán FC | 2:1 (1:0) | ||
| 20.10.2021 | 16:00 | Deportivo Toluca | - | Club Necaxa | 0:1 (0:1) | |
| 16:00 | Club León | - | Pumas UNAM | 0:2 (0:1) | ||
| 16:00 | UANL Tigres | - | CF Pachuca | 2:1 (0:1) | ||
| 21.10.2021 | 00:45 | Club Tijuana | - | Deportivo Guadalajara | 1:2 (1:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Santos Laguna | 14 | 7 | 4 | 3 | 28:20 | 8 | 25 |
| 2 |
|
Deportivo Toluca | 14 | 7 | 2 | 5 | 20:16 | 4 | 23 |
| 3 |
|
Deportivo Guadalajara | 14 | 7 | 2 | 5 | 22:21 | 1 | 23 |
| 4 |
|
Cruz Azul | 14 | 5 | 7 | 2 | 11:7 | 4 | 22 |
| 5 |
|
Atlas Guadalajara | 14 | 6 | 3 | 5 | 19:19 | 0 | 21 |
| 6 |
|
Club León | 14 | 6 | 3 | 5 | 15:15 | 0 | 21 |
| 7 |
|
Club Necaxa | 14 | 5 | 5 | 4 | 22:19 | 3 | 20 |
| 8 |
|
CF América | 14 | 5 | 5 | 4 | 20:17 | 3 | 20 |
| 9 |
|
UANL Tigres | 14 | 6 | 2 | 6 | 19:17 | 2 | 20 |
| 10 |
|
Atlético San Luis | 14 | 6 | 2 | 6 | 23:22 | 1 | 20 |
| 11 |
|
Pumas UNAM | 14 | 5 | 3 | 6 | 22:23 | -1 | 18 |
| 12 |
|
Puebla FC | 14 | 4 | 6 | 4 | 23:26 | -3 | 18 |
| 13 |
|
Mazatlán FC | 14 | 5 | 3 | 6 | 25:29 | -4 | 18 |
| 14 |
|
Club Tijuana | 14 | 4 | 5 | 5 | 22:23 | -1 | 17 |
| 15 |
|
Gallos Blancos | 14 | 4 | 5 | 5 | 18:19 | -1 | 17 |
| 16 |
|
CF Monterrey | 14 | 4 | 4 | 6 | 19:19 | 0 | 16 |
| 17 |
|
CF Pachuca | 14 | 3 | 7 | 4 | 16:17 | -1 | 16 |
| 18 |
|
FC Juárez | 14 | 1 | 4 | 9 | 10:25 | -15 | 7 |
| Playoff |
