| 1. Jornada | 09.01.2021 | CF América [Sub 20] | - | Atlético San Luis [Sub 20] | 4:1 | ||||
| 12. Jornada | 20.03.2021 | Atlético San Luis [Sub 20] | - | Pumas UNAM [Sub 20] | 2:1 | ||||
| 4. Jornada | 26.03.2021 | Club León [Sub 20] | - | Atlético San Luis [Sub 20] | 4:2 |  |
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| 13. Jornada | 03.04.2021 | CF Monterrey [Sub 20] | - | Atlético San Luis [Sub 20] | 4:1 | ||||
| 14. Jornada | 09.04.2021 | FC Juárez [Sub 20] | - | Atlético San Luis [Sub 20] | 2:2 | ||||
| 15. Jornada | 17.04.2021 | Atlético San Luis [Sub 20] | - | Puebla FC [Sub 20] | 5:3 | ||||
| 16. Jornada | 24.04.2021 | Cruz Azul [Sub 20] | - | Atlético San Luis [Sub 20] | 0:1 | ||||
| 17. Jornada | 29.04.2021 | Atlético San Luis [Sub 20] | - | CF Pachuca [Sub 20] | 2:0 |
México