| 19. Jornada | 30.01.2022 | FC Wil 1900 | - | FC Vaduz | 4:4 |  |
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| 20. Jornada | 05.02.2022 | FC Thun | - | FC Wil 1900 | 3:0 | ||||
| 21. Jornada | 12.02.2022 | FC Winterthur | - | FC Wil 1900 | 4:0 | ||||
| 22. Jornada | 19.02.2022 | FC Wil 1900 | - | FC Schaffhausen | 3:2 | |
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| 23. Jornada | 25.02.2022 | FC Aarau | - | FC Wil 1900 | 2:1 | ||||
| 24. Jornada | 01.03.2022 | FC Wil 1900 | - | SC Kriens | 3:1 | ||||
| 25. Jornada | 04.03.2022 | Yverdon Sport FC | - | FC Wil 1900 | 2:2 | ||||
| 26. Jornada | 12.03.2022 | FC Wil 1900 | - | Neuchâtel Xamax FCS | 2:0 | ||||
| 27. Jornada | 19.03.2022 | Stade Lausanne-Ouchy | - | FC Wil 1900 | 1:1 | ||||
| 28. Jornada | 01.04.2022 | FC Wil 1900 | - | FC Aarau | 3:4 | |
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| 29. Jornada | 09.04.2022 | SC Kriens | - | FC Wil 1900 | 2:1 | ||||
| 30. Jornada | 16.04.2022 | FC Wil 1900 | - | Stade Lausanne-Ouchy | 3:0 | ||||
| 32. Jornada | 30.04.2022 | FC Wil 1900 | - | Yverdon Sport FC | 2:2 | ||||
| 33. Jornada | 06.05.2022 | FC Vaduz | - | FC Wil 1900 | 5:2 | |
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| 34. Jornada | 09.05.2022 | FC Wil 1900 | - | FC Winterthur | 1:1 | ||||
| 35. Jornada | 14.05.2022 | FC Wil 1900 | - | FC Thun | 1:2 | ||||
| 36. Jornada | 21.05.2022 | Neuchâtel Xamax FCS | - | FC Wil 1900 | 5:2 | |
Senegal