| 1. Jornada | 10.01.2022 | Deportivo Guadalajara | - | Mazatlán FC | 3:0 | ||||
| 3. Jornada | 22.01.2022 | Mazatlán FC | - | Deportivo Toluca | 1:2 | ||||
| 4. Jornada | 07.02.2022 | UANL Tigres | - | Mazatlán FC | 4:3 | ||||
| 5. Jornada | 12.02.2022 | Mazatlán FC | - | Club Tijuana | 2:0 |  |
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| 2. Jornada | 17.02.2022 | Mazatlán FC | - | CF América | 2:1 | |
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| 6. Jornada | 20.02.2022 | Gallos Blancos | - | Mazatlán FC | 2:0 | |
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| 7. Jornada | 25.02.2022 | CF Pachuca | - | Mazatlán FC | 3:1 | ||||
| 8. Jornada | 02.03.2022 | Mazatlán FC | - | Club Necaxa | 0:0 |
Brasil