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| 18.02.2022 | 22:15 | Nacional Potosí | - | Real Santa Cruz | 1:0 (1:0) | |
| 19.02.2022 | 00:30 | The Strongest | - | Universitario de Sucre | 1:1 (1:0) | |
| 22:15 | Club Aurora | - | Atlético Palmaflor | 1:2 (0:0) | ||
| 22:15 | Always Ready | - | Real Tomayapo | 0:1 (0:0) | ||
| 20.02.2022 | 00:30 | Royal Pari | - | Blooming | 1:1 (0:0) | |
| 20:00 | Universitario de Vinto | - | Jorge Wilstermann | 2:0 (1:0) | ||
| 22:15 | Independiente Petrolero | - | Bolívar | 1:0 (0:0) | ||
| 21.02.2022 | 00:30 | Oriente Petrolero | - | CD Guabirá | 2:1 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| 1 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
The Strongest | 3 | 2 | 1 | 0 | 6:1 | 5 | 7 |
| 2 |
|
Universitario de Sucre | 3 | 2 | 1 | 0 | 6:4 | 2 | 7 |
| 3 |
|
Oriente Petrolero | 3 | 2 | 0 | 1 | 4:3 | 1 | 6 |
| 4 |
|
Nacional Potosí | 3 | 1 | 1 | 1 | 5:5 | 0 | 4 |
| 5 |
|
Atlético Palmaflor | 3 | 1 | 1 | 1 | 3:5 | -2 | 4 |
| 6 |
|
CD Guabirá | 3 | 0 | 2 | 1 | 3:4 | -1 | 2 |
| 7 |
|
Real Santa Cruz | 3 | 0 | 1 | 2 | 2:4 | -2 | 1 |
| 8 |
|
Club Aurora | 3 | 0 | 1 | 2 | 1:4 | -3 | 1 |
| 2 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Bolívar | 3 | 2 | 0 | 1 | 9:1 | 8 | 6 |
| 2 |
|
Real Tomayapo | 3 | 1 | 2 | 0 | 3:2 | 1 | 5 |
| 3 |
|
Always Ready | 3 | 1 | 1 | 1 | 4:4 | 0 | 4 |
| 4 |
|
Independiente Petrolero | 3 | 1 | 1 | 1 | 3:3 | 0 | 4 |
|
Universitario de Vinto | 3 | 1 | 1 | 1 | 3:3 | 0 | 4 | |
| 6 |
|
Blooming | 3 | 1 | 1 | 1 | 2:8 | -6 | 4 |
| 7 |
|
Jorge Wilstermann | 3 | 1 | 0 | 2 | 2:3 | -1 | 3 |
| 8 |
|
Royal Pari | 3 | 0 | 2 | 1 | 3:5 | -2 | 2 |
| Playoff | |
| Playoff |
