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| 16.01.2021 | 00:00 | Mineros de Fresnillo FC | - | Saltillo FC | 2:2 (2:0) | |
| 18:00 | Tecos Fútbol Club | - | Leones Negros II | 2:3 (1:1) | ||
| 19:00 | Atlético San Luis II | - | Alacranes de Durango | 1:1 (1:0) | ||
| 22:00 | Reboceros de La Piedad | - | Tuzos de la UAZ | 4:3 (2:2) | ||
| 22:30 | Mazorqueros | - | Cimarrones de Sonora II | 1:1 (0:1) | ||
| 17.01.2021 | 22:00 | Gavilanes de Matamoros | - | Colima FC | 0:0 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Alacranes de Durango | 12 | 8 | 2 | 2 | 24:10 | 14 | 29 |
| 2 |
|
Colima FC | 12 | 7 | 3 | 2 | 17:8 | 9 | 28 |
| 3 |
|
Reboceros de La Piedad | 12 | 7 | 2 | 3 | 27:15 | 12 | 27 |
| 4 |
|
Mineros de Fresnillo FC | 12 | 6 | 3 | 3 | 25:16 | 9 | 24 |
| 5 |
|
Gavilanes de Matamoros | 12 | 7 | 2 | 3 | 10:9 | 1 | 23 |
| 6 |
|
Mazorqueros | 12 | 5 | 2 | 5 | 14:17 | -3 | 17 |
| 7 |
|
Atlético San Luis II | 12 | 4 | 2 | 6 | 10:14 | -4 | 16 |
| 8 |
|
Saltillo FC | 12 | 2 | 6 | 4 | 11:20 | -9 | 14 |
| 9 |
|
Tuzos de la UAZ | 12 | 2 | 5 | 5 | 12:16 | -4 | 13 |
| 10 |
|
Leones Negros II | 12 | 3 | 2 | 7 | 14:23 | -9 | 12 |
| 11 |
|
Tecos Fútbol Club | 12 | 2 | 3 | 7 | 9:16 | -7 | 10 |
| 12 |
|
Cimarrones de Sonora II | 12 | 1 | 4 | 7 | 8:17 | -9 | 7 |
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