 |
 |
|
|
| 02.10.2021 | 02:00 | Puebla FC | - | CF Pachuca | 1:2 (1:1) | |
| 04:00 | FC Juárez | - | CF Monterrey | 3:1 (2:1) | ||
| 03.10.2021 | 00:00 | Club León | - | Atlético San Luis | 0:0 (0:0) | |
| 02:06 | Santos Laguna | - | Mazatlán FC | 1:0 (1:0) | ||
| 04:00 | Deportivo Guadalajara | - | Atlas Guadalajara | 0:1 (0:1) | ||
| 19:00 | Deportivo Toluca | - | Gallos Blancos | 1:1 (0:0) | ||
| 04.10.2021 | 00:00 | CF América | - | Pumas UNAM | 2:0 (1:0) | |
| 02:00 | UANL Tigres | - | Club Necaxa | 0:0 (0:0) | ||
| 04:06 | Club Tijuana | - | Cruz Azul | 0:1 (0:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF América | 12 | 7 | 4 | 1 | 16:7 | 9 | 25 |
| 2 |
|
Atlas Guadalajara | 12 | 6 | 4 | 2 | 13:5 | 8 | 22 |
| 3 |
|
Deportivo Toluca | 12 | 6 | 3 | 3 | 19:16 | 3 | 21 |
| 4 |
|
CF Monterrey | 12 | 5 | 5 | 2 | 18:12 | 6 | 20 |
| 5 |
|
Club León | 12 | 5 | 4 | 3 | 14:12 | 2 | 19 |
| 6 |
|
Santos Laguna | 12 | 4 | 6 | 2 | 16:9 | 7 | 18 |
| 7 |
|
UANL Tigres | 12 | 4 | 6 | 2 | 17:11 | 6 | 18 |
| 8 |
|
Atlético San Luis | 12 | 4 | 6 | 2 | 16:14 | 2 | 18 |
| 9 |
|
Cruz Azul | 12 | 4 | 5 | 3 | 14:10 | 4 | 17 |
| 10 |
|
CF Pachuca | 12 | 4 | 3 | 5 | 14:12 | 2 | 15 |
| 11 |
|
Deportivo Guadalajara | 12 | 3 | 5 | 4 | 8:10 | -2 | 14 |
| 12 |
|
Mazatlán FC | 12 | 3 | 5 | 4 | 14:18 | -4 | 14 |
| 13 |
|
Club Necaxa | 12 | 4 | 1 | 7 | 12:16 | -4 | 13 |
| 14 |
|
Puebla FC | 12 | 2 | 6 | 4 | 10:15 | -5 | 12 |
| 15 |
|
FC Juárez | 12 | 3 | 3 | 6 | 12:18 | -6 | 12 |
| 16 |
|
Gallos Blancos | 12 | 2 | 5 | 5 | 6:11 | -5 | 11 |
| 17 |
|
Pumas UNAM | 12 | 1 | 5 | 6 | 6:17 | -11 | 8 |
| 18 |
|
Club Tijuana | 12 | 1 | 4 | 7 | 9:21 | -12 | 7 |
| Playoff | |
| Playoff |
