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| 30.03.2022 | 18:00 | Pumas UNAM | - | Gallos Blancos | 3:0 (2:0) | |
| 05.04.2022 | 16:00 | Atlético San Luis | - | Club Tijuana | 3:1 (1:1) | |
| 09.04.2022 | 17:00 | Club León | - | Atlas Guadalajara | 0:2 (0:1) | |
| 19:00 | CF Pachuca | - | Club Necaxa | 1:2 (1:1) | ||
| 20:30 | Mazatlán FC | - | Deportivo Guadalajara | 1:2 (1:2) | ||
| 10.04.2022 | 16:00 | Deportivo Toluca | - | FC Juárez | 7:0 (4:0) | |
| 27.04.2022 | 16:00 | CF Monterrey | - | UANL Tigres | 2:3 (0:0) | |
| 19:45 | CF América | - | Cruz Azul | 1:0 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| 1 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Toluca | 13 | 7 | 2 | 4 | 32:17 | 15 | 23 |
| 2 |
|
Cruz Azul | 13 | 7 | 2 | 4 | 29:18 | 11 | 23 |
| 3 |
|
Pumas UNAM | 12 | 7 | 2 | 3 | 18:8 | 10 | 23 |
| 4 |
|
Club Necaxa | 12 | 6 | 4 | 2 | 19:19 | 0 | 22 |
| 5 |
|
CF América | 12 | 6 | 1 | 5 | 16:14 | 2 | 19 |
| 6 |
|
CF Pachuca | 13 | 4 | 5 | 4 | 25:24 | 1 | 17 |
| 7 |
|
Puebla FC | 12 | 4 | 2 | 6 | 20:19 | 1 | 14 |
| 8 |
|
Gallos Blancos | 13 | 2 | 3 | 8 | 9:26 | -17 | 9 |
| 9 |
|
FC Juárez | 12 | 2 | 1 | 9 | 15:38 | -23 | 7 |
| 2 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 12 | 9 | 2 | 1 | 28:10 | 18 | 29 |
| 2 |
|
Atlas Guadalajara | 12 | 7 | 3 | 2 | 26:15 | 11 | 24 |
| 3 |
|
UANL Tigres | 13 | 6 | 4 | 3 | 18:16 | 2 | 22 |
| 4 |
|
Santos Laguna | 12 | 6 | 2 | 4 | 19:14 | 5 | 20 |
| 5 |
|
CF Monterrey | 13 | 3 | 6 | 4 | 20:18 | 2 | 15 |
| 6 |
|
Club León | 12 | 4 | 2 | 6 | 14:20 | -6 | 14 |
| 7 |
|
Club Tijuana | 12 | 4 | 1 | 7 | 11:20 | -9 | 13 |
| 8 |
|
Atlético San Luis | 13 | 2 | 3 | 8 | 13:22 | -9 | 9 |
| 9 |
|
Mazatlán FC | 13 | 2 | 3 | 8 | 16:30 | -14 | 9 |
| Playoff | |
| Playoff |
