 |
 |
|
| 12.08.2021 | 18:45 | Atlético San Luis | - | Club Necaxa | 3:3 (0:2) | |
| 13.08.2021 | 18:45 | Puebla FC | - | UANL Tigres | 1:2 (0:0) | |
| 19:30 | FC Juárez | - | Club Tijuana | 3:2 (3:1) | ||
| 14.08.2021 | 18:30 | Cruz Azul | - | Deportivo Toluca | 0:0 (0:0) | |
| 18:30 | Club León | - | Mazatlán FC | 1:1 (1:0) | ||
| 18:30 | CF Monterrey | - | CF Pachuca | 1:2 (0:0) | ||
| 18:30 | Pumas UNAM | - | Gallos Blancos | 0:0 (0:0) | ||
| 15.08.2021 | 16:00 | Santos Laguna | - | Deportivo Guadalajara | 1:1 (1:1) | |
| 18:30 | Atlas Guadalajara | - | CF América | 1:3 (0:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Necaxa | 4 | 3 | 1 | 0 | 14:6 | 8 | 10 |
| 2 |
|
CF América | 4 | 3 | 0 | 1 | 8:5 | 3 | 9 |
| 3 |
|
CF Pachuca | 4 | 2 | 2 | 0 | 9:4 | 5 | 8 |
| 4 |
|
Deportivo Guadalajara | 4 | 2 | 1 | 1 | 11:4 | 7 | 7 |
| 5 |
|
Deportivo Toluca | 4 | 2 | 1 | 1 | 6:4 | 2 | 7 |
| 6 |
|
Atlas Guadalajara | 4 | 2 | 1 | 1 | 6:6 | 0 | 7 |
| 7 |
|
Club León | 4 | 2 | 1 | 1 | 5:7 | -2 | 7 |
| 8 |
|
Club Tijuana | 4 | 2 | 0 | 2 | 7:5 | 2 | 6 |
| 9 |
|
Mazatlán FC | 4 | 1 | 3 | 0 | 5:4 | 1 | 6 |
| 10 |
|
FC Juárez | 4 | 2 | 0 | 2 | 7:7 | 0 | 6 |
| 11 |
|
Pumas UNAM | 4 | 1 | 2 | 1 | 4:4 | 0 | 5 |
| 12 |
|
Cruz Azul | 4 | 1 | 2 | 1 | 3:7 | -4 | 5 |
| 13 |
|
Atlético San Luis | 4 | 1 | 2 | 1 | 5:10 | -5 | 5 |
| 14 |
|
UANL Tigres | 4 | 1 | 1 | 2 | 2:6 | -4 | 4 |
| 15 |
|
Santos Laguna | 4 | 0 | 2 | 2 | 3:6 | -3 | 2 |
| 16 |
|
CF Monterrey | 4 | 0 | 1 | 3 | 3:6 | -3 | 1 |
| 17 |
|
Gallos Blancos | 4 | 0 | 1 | 3 | 1:4 | -3 | 1 |
| 18 |
|
Puebla FC | 4 | 0 | 1 | 3 | 2:6 | -4 | 1 |
| Playoff |
