 |
 |
|
| 17.08.2021 | 18:00 | UANL Tigres | - | Gallos Blancos | 1:0 (1:0) | |
| 18:15 | Club Necaxa | - | Pumas UNAM | 4:2 (3:1) | ||
| 18:30 | Deportivo Toluca | - | Mazatlán FC | 0:1 (0:0) | ||
| 21:45 | Club Tijuana | - | Puebla FC | 5:2 (2:2) | ||
| 18.08.2021 | 16:00 | Santos Laguna | - | Atlas Guadalajara | 2:3 (1:0) | |
| 18:15 | Deportivo Guadalajara | - | Club León | 1:1 (1:0) | ||
| 18:30 | Cruz Azul | - | CF Monterrey | 1:1 (1:0) | ||
| 19:30 | FC Juárez | - | CF América | 2:2 (0:1) | ||
| 03.11.2021 | 16:30 | CF Pachuca | - | Atlético San Luis | 3:2 (1:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Necaxa | 5 | 4 | 1 | 0 | 18:8 | 10 | 13 |
| 2 |
|
CF Pachuca | 5 | 3 | 2 | 0 | 12:6 | 6 | 11 |
| 3 |
|
CF América | 5 | 3 | 1 | 1 | 10:7 | 3 | 10 |
| 4 |
|
Atlas Guadalajara | 5 | 3 | 1 | 1 | 9:8 | 1 | 10 |
| 5 |
|
Club Tijuana | 5 | 3 | 0 | 2 | 12:7 | 5 | 9 |
| 6 |
|
Mazatlán FC | 5 | 2 | 3 | 0 | 6:4 | 2 | 9 |
| 7 |
|
Deportivo Guadalajara | 5 | 2 | 2 | 1 | 12:5 | 7 | 8 |
| 8 |
|
Club León | 5 | 2 | 2 | 1 | 6:8 | -2 | 8 |
| 9 |
|
Deportivo Toluca | 5 | 2 | 1 | 2 | 6:5 | 1 | 7 |
| 10 |
|
FC Juárez | 5 | 2 | 1 | 2 | 9:9 | 0 | 7 |
| 11 |
|
UANL Tigres | 5 | 2 | 1 | 2 | 3:6 | -3 | 7 |
| 12 |
|
Cruz Azul | 5 | 1 | 3 | 1 | 4:8 | -4 | 6 |
| 13 |
|
Pumas UNAM | 5 | 1 | 2 | 2 | 6:8 | -2 | 5 |
| 14 |
|
Atlético San Luis | 5 | 1 | 2 | 2 | 7:13 | -6 | 5 |
| 15 |
|
CF Monterrey | 5 | 0 | 2 | 3 | 4:7 | -3 | 2 |
| 16 |
|
Santos Laguna | 5 | 0 | 2 | 3 | 5:9 | -4 | 2 |
| 17 |
|
Gallos Blancos | 5 | 0 | 1 | 4 | 1:5 | -4 | 1 |
| 18 |
|
Puebla FC | 5 | 0 | 1 | 4 | 4:11 | -7 | 1 |
| Playoff |
