 |
 |
|
| 20.08.2021 | 19:15 | Mazatlán FC | - | UANL Tigres | 0:4 (0:1) | |
| 21.08.2021 | 18:30 | Atlas Guadalajara | - | Deportivo Toluca | 2:0 (1:0) | |
| 18:30 | Club León | - | Santos Laguna | 3:1 (1:0) | ||
| 18:30 | CF Monterrey | - | Deportivo Guadalajara | 2:2 (1:2) | ||
| 18:45 | Atlético San Luis | - | Cruz Azul | 2:3 (2:2) | ||
| 22.08.2021 | 18:00 | CF América | - | Club Tijuana | 4:0 (1:0) | |
| 18:15 | Club Necaxa | - | FC Juárez | 3:2 (1:1) | ||
| 18:30 | Gallos Blancos | - | CF Pachuca | 1:0 (0:0) | ||
| 18:30 | Pumas UNAM | - | Puebla FC | 3:3 (1:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Necaxa | 6 | 5 | 1 | 0 | 21:10 | 11 | 16 |
| 2 |
|
CF América | 6 | 4 | 1 | 1 | 14:7 | 7 | 13 |
| 3 |
|
Atlas Guadalajara | 6 | 4 | 1 | 1 | 11:8 | 3 | 13 |
| 4 |
|
CF Pachuca | 6 | 3 | 2 | 1 | 12:7 | 5 | 11 |
| 5 |
|
Club León | 6 | 3 | 2 | 1 | 9:9 | 0 | 11 |
| 6 |
|
UANL Tigres | 6 | 3 | 1 | 2 | 7:6 | 1 | 10 |
| 7 |
|
Deportivo Guadalajara | 6 | 2 | 3 | 1 | 14:7 | 7 | 9 |
| 8 |
|
Club Tijuana | 6 | 3 | 0 | 3 | 12:11 | 1 | 9 |
| 9 |
|
Mazatlán FC | 6 | 2 | 3 | 1 | 6:8 | -2 | 9 |
| 10 |
|
Cruz Azul | 6 | 2 | 3 | 1 | 7:10 | -3 | 9 |
| 11 |
|
FC Juárez | 6 | 2 | 1 | 3 | 11:12 | -1 | 7 |
| 12 |
|
Deportivo Toluca | 6 | 2 | 1 | 3 | 6:7 | -1 | 7 |
| 13 |
|
Pumas UNAM | 6 | 1 | 3 | 2 | 9:11 | -2 | 6 |
| 14 |
|
Atlético San Luis | 6 | 1 | 2 | 3 | 9:16 | -7 | 5 |
| 15 |
|
Gallos Blancos | 6 | 1 | 1 | 4 | 2:5 | -3 | 4 |
| 16 |
|
CF Monterrey | 6 | 0 | 3 | 3 | 6:9 | -3 | 3 |
| 17 |
|
Santos Laguna | 6 | 0 | 2 | 4 | 6:12 | -6 | 2 |
| 18 |
|
Puebla FC | 6 | 0 | 2 | 4 | 7:14 | -7 | 2 |
| Playoff |
