 |
 |
|
| 27.08.2021 | 18:45 | Puebla FC | - | Gallos Blancos | 2:3 (0:1) | |
| 19:15 | Mazatlán FC | - | Atlético San Luis | 5:1 (5:1) | ||
| 21:45 | Club Tijuana | - | CF Monterrey | 0:0 (0:0) | ||
| 28.08.2021 | 18:15 | UANL Tigres | - | Atlas Guadalajara | 0:0 (0:0) | |
| 18:15 | Deportivo Guadalajara | - | Club Necaxa | 1:2 (0:1) | ||
| 18:30 | Club León | - | CF América | 0:1 (0:1) | ||
| 29.08.2021 | 16:00 | Santos Laguna | - | FC Juárez | 0:0 (0:0) | |
| 18:30 | Cruz Azul | - | CF Pachuca | 1:0 (0:0) | ||
| 18:30 | Deportivo Toluca | - | Pumas UNAM | 2:0 (1:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Necaxa | 7 | 6 | 1 | 0 | 23:11 | 12 | 19 |
| 2 |
|
CF América | 7 | 5 | 1 | 1 | 15:7 | 8 | 16 |
| 3 |
|
Atlas Guadalajara | 7 | 4 | 2 | 1 | 11:8 | 3 | 14 |
| 4 |
|
Mazatlán FC | 7 | 3 | 3 | 1 | 11:9 | 2 | 12 |
| 5 |
|
Cruz Azul | 7 | 3 | 3 | 1 | 8:10 | -2 | 12 |
| 6 |
|
CF Pachuca | 7 | 3 | 2 | 2 | 12:8 | 4 | 11 |
| 7 |
|
UANL Tigres | 7 | 3 | 2 | 2 | 7:6 | 1 | 11 |
| 8 |
|
Club León | 7 | 3 | 2 | 2 | 9:10 | -1 | 11 |
| 9 |
|
Club Tijuana | 7 | 3 | 1 | 3 | 12:11 | 1 | 10 |
| 10 |
|
Deportivo Toluca | 7 | 3 | 1 | 3 | 8:7 | 1 | 10 |
| 11 |
|
Deportivo Guadalajara | 7 | 2 | 3 | 2 | 15:9 | 6 | 9 |
| 12 |
|
FC Juárez | 7 | 2 | 2 | 3 | 11:12 | -1 | 8 |
| 13 |
|
Gallos Blancos | 7 | 2 | 1 | 4 | 5:7 | -2 | 7 |
| 14 |
|
Pumas UNAM | 7 | 1 | 3 | 3 | 9:13 | -4 | 6 |
| 15 |
|
Atlético San Luis | 7 | 1 | 2 | 4 | 10:21 | -11 | 5 |
| 16 |
|
CF Monterrey | 7 | 0 | 4 | 3 | 6:9 | -3 | 4 |
| 17 |
|
Santos Laguna | 7 | 0 | 3 | 4 | 6:12 | -6 | 3 |
| 18 |
|
Puebla FC | 7 | 0 | 2 | 5 | 9:17 | -8 | 2 |
| Playoff |
