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| I | UANL Tigres | - | Cruz Azul | 0:0 (0:0) | ||
| V | Cruz Azul | - | UANL Tigres | 0:0 (0:0) | ||
| I: 24.11.2021 16:00 | V: 27.11.2021 16:00 | |||||
| I | Atlas Guadalajara | - | Santos Laguna | 0:1 (0:1) | ||
| V | Santos Laguna | - | Atlas Guadalajara | 0:1 (0:1) | ||
| I: 25.11.2021 16:00 | V: 28.11.2021 18:00 | |||||
|
|
|
|
| I | UANL Tigres | - | Cruz Azul | 0:0 (0:0) | ||
| V | Cruz Azul | - | UANL Tigres | 0:0 (0:0) | ||
| I: 24.11.2021 16:00 | V: 27.11.2021 16:00 | |||||
| I | Atlas Guadalajara | - | Santos Laguna | 0:1 (0:1) | ||
| V | Santos Laguna | - | Atlas Guadalajara | 0:1 (0:1) | ||
| I: 25.11.2021 16:00 | V: 28.11.2021 18:00 | |||||
