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| 09.04.2022 | 11:00 | Kuban Krasnodar | - | Spartak Moskva | 1:2 (0:2) | |
| 13:00 | FK Saturn | - | Dinamo Moskva | 2:1 (0:0) | ||
| 13:00 | FK Krasnodar | - | CSKA Moscú | 5:2 (2:2) | ||
| 13:00 | FShM Moskva | - | FK Strogino Moskva | 2:3 (1:1) | ||
| 13:30 | FK Rostov | - | SShOR Zenit | 0:1 (0:1) | ||
| 14:00 | Zenit | - | Lokomotiv Moskva | 3:1 (0:1) | ||
| 14:00 | Rubin Kazan | - | Chertanovo Football Academy | 0:3 (0:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Spartak Moskva | 20 | 14 | 3 | 3 | 53:16 | 37 | 45 |
| 2 |
|
FK Krasnodar | 20 | 13 | 4 | 3 | 48:19 | 29 | 43 |
| 3 |
|
Chertanovo Football Academy | 20 | 13 | 2 | 5 | 51:28 | 23 | 41 |
| 4 |
|
Zenit | 20 | 12 | 4 | 4 | 54:29 | 25 | 40 |
| 5 |
|
FK Rostov | 20 | 11 | 5 | 4 | 32:18 | 14 | 38 |
| 6 |
|
FK Strogino Moskva | 20 | 12 | 1 | 7 | 36:25 | 11 | 37 |
| 7 |
|
Lokomotiv Moskva | 20 | 10 | 2 | 8 | 40:37 | 3 | 32 |
| 8 |
|
FK Saturn | 20 | 7 | 4 | 9 | 30:48 | -18 | 25 |
| 9 |
|
SShOR Zenit | 20 | 7 | 3 | 10 | 30:40 | -10 | 24 |
| 10 |
|
CSKA Moscú | 20 | 6 | 4 | 10 | 34:44 | -10 | 22 |
| 11 |
|
Kuban Krasnodar | 20 | 4 | 5 | 11 | 17:44 | -27 | 17 |
| 12 |
|
Dinamo Moskva | 20 | 3 | 4 | 13 | 25:44 | -19 | 13 |
| 13 |
|
FShM Moskva | 20 | 2 | 4 | 14 | 23:57 | -34 | 10 |
| 14 |
|
Rubin Kazan | 20 | 1 | 5 | 14 | 17:41 | -24 | 8 |
