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| 21.05.2022 | 16:00 | Arsenal Tula | - | FK Ural | 1:2 (1:2) | |
| 16:00 | Dinamo Moskva | - | FK Sochi | 1:5 (1:4) | ||
| 16:00 | FK Krasnodar | - | Akhmat Grozny | 1:1 (0:0) | ||
| 16:00 | FK Khimki | - | Spartak Moskva | 2:1 (2:1) | ||
| 16:00 | Krylia Sovetov | - | Lokomotiv Moskva | 0:1 (0:0) | ||
| 16:00 | FK Nizhny Novgorod | - | Zenit | 1:0 (1:0) | ||
| 16:00 | Rubin Kazan | - | FK Ufa | 1:2 (1:0) | ||
| 16:00 | CSKA Moscú | - | FK Rostov | 4:0 (2:0) |
| » Clasificación | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Zenit | 30 | 19 | 8 | 3 | 66:28 | 38 | 65 |
| 2 |
|
FK Sochi | 30 | 17 | 5 | 8 | 54:30 | 24 | 56 |
| 3 |
|
Dinamo Moskva | 30 | 16 | 5 | 9 | 53:41 | 12 | 53 |
| 4 |
|
FK Krasnodar | 30 | 14 | 8 | 8 | 42:30 | 12 | 50 |
| 5 |
|
CSKA Moscú | 30 | 15 | 5 | 10 | 42:29 | 13 | 50 |
| 6 |
|
Lokomotiv Moskva | 30 | 13 | 9 | 8 | 43:39 | 4 | 48 |
| 7 |
|
Akhmat Grozny | 30 | 13 | 3 | 14 | 36:38 | -2 | 42 |
| 8 |
|
Krylia Sovetov | 30 | 12 | 5 | 13 | 39:36 | 3 | 41 |
| 9 |
|
FK Rostov | 30 | 10 | 8 | 12 | 47:51 | -4 | 38 |
| 10 |
|
Spartak Moskva | 30 | 10 | 8 | 12 | 37:41 | -4 | 38 |
| 11 |
|
FK Nizhny Novgorod | 30 | 8 | 9 | 13 | 26:39 | -13 | 33 |
| 12 |
|
FK Ural | 30 | 8 | 9 | 13 | 27:35 | -8 | 33 |
| 13 |
|
FK Khimki | 30 | 7 | 11 | 12 | 34:47 | -13 | 32 |
| 14 |
|
FK Ufa | 30 | 6 | 12 | 12 | 29:40 | -11 | 30 |
| 15 |
|
Rubin Kazan | 30 | 8 | 5 | 17 | 34:56 | -22 | 29 |
| 16 |
|
Arsenal Tula | 30 | 5 | 8 | 17 | 30:59 | -29 | 23 |
| Permanencia | |
| Descenso |
