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| 05.05.2021 | 11:00 | FK Rostov | - | CSKA Moskva | 3:1 (1:0) | |
| 12:00 | PFC Sochi | - | Rubin Kazan | 1:1 (0:1) | ||
| 14:30 | FK Krasnodar | - | FK Strogino Moskva | 2:0 (0:0) | ||
| 15:00 | Akhmat Grozny | - | Zenit St. Petersburg | 4:3 (2:1) | ||
| 16:00 | Spartak Moskva | - | Lokomotiv Moskva | 1:1 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª parte | 2.ª parte |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FK Krasnodar | 24 | 19 | 2 | 3 | 54:18 | 36 | 59 |
| 2 |
|
CSKA Moskva | 24 | 19 | 1 | 4 | 71:26 | 45 | 58 |
| 3 |
|
Zenit St. Petersburg | 24 | 18 | 2 | 4 | 64:24 | 40 | 56 |
| 4 |
|
Spartak Moskva | 24 | 15 | 5 | 4 | 46:22 | 24 | 50 |
| 5 |
|
Lokomotiv Moskva | 24 | 14 | 4 | 6 | 45:19 | 26 | 46 |
| 6 |
|
Akhmat Grozny | 24 | 13 | 6 | 5 | 45:33 | 12 | 45 |
| 7 |
|
Rubin Kazan | 24 | 9 | 6 | 9 | 27:27 | 0 | 33 |
| 8 |
|
FK Rostov | 24 | 8 | 7 | 9 | 38:36 | 2 | 31 |
| 9 |
|
PFC Sochi | 24 | 7 | 8 | 9 | 29:30 | -1 | 29 |
| 10 |
|
FK Strogino Moskva | 24 | 8 | 4 | 12 | 35:46 | -11 | 28 |
