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| 04.12.2021 | 11:30 | Bandırmaspor | - | Gençlerbirliği | 1:2 (0:0) | |
| 11:30 | BB Erzurumspor | - | İstanbulspor AŞ | 3:1 (2:1) | ||
| 16:00 | Adanaspor | - | Tuzlaspor | 1:1 (0:0) | ||
| 05.12.2021 | 11:30 | Manisa FK | - | Kocaelispor | 2:1 (0:0) | |
| 11:30 | Ümraniyespor | - | Boluspor | 1:2 (0:1) | ||
| 14:00 | Altınordu FK | - | Samsunspor | 0:2 (0:1) | ||
| 17:00 | Denizlispor | - | Bursaspor | 1:3 (0:2) | ||
| 06.12.2021 | 18:00 | MKE Ankaragücü | - | Balıkesirspor | 2:0 (1:0) | |
| 18:00 | Menemen Belediyespor | - | Keçiörengücü | 2:2 (1:2) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
MKE Ankaragücü | 15 | 9 | 3 | 3 | 25:11 | 14 | 30 |
| 2 |
|
BB Erzurumspor | 14 | 9 | 2 | 3 | 24:15 | 9 | 29 |
| 3 |
|
Eyüpspor | 14 | 8 | 3 | 3 | 24:18 | 6 | 27 |
| 4 |
|
Ümraniyespor | 14 | 8 | 3 | 3 | 24:12 | 12 | 27 |
| 5 |
|
Bandırmaspor | 14 | 8 | 1 | 5 | 22:12 | 10 | 25 |
| 6 |
|
Tuzlaspor | 14 | 6 | 4 | 4 | 16:12 | 4 | 22 |
| 7 |
|
Samsunspor | 14 | 6 | 4 | 4 | 20:18 | 2 | 22 |
| 8 |
|
İstanbulspor AŞ | 14 | 6 | 2 | 6 | 23:21 | 2 | 20 |
| 9 |
|
Kocaelispor | 14 | 6 | 2 | 6 | 14:16 | -2 | 20 |
| 10 |
|
Gençlerbirliği | 14 | 6 | 2 | 6 | 16:20 | -4 | 20 |
| 11 |
|
Boluspor | 14 | 5 | 4 | 5 | 18:16 | 2 | 19 |
| 12 |
|
Adanaspor | 15 | 5 | 4 | 6 | 17:19 | -2 | 19 |
| 13 |
|
Menemen Belediyespor | 14 | 5 | 3 | 6 | 20:25 | -5 | 18 |
| 14 |
|
Bursaspor | 14 | 5 | 2 | 7 | 20:22 | -2 | 17 |
| 15 |
|
Manisa FK | 15 | 5 | 2 | 8 | 17:22 | -5 | 17 |
| 16 |
|
Denizlispor | 14 | 4 | 3 | 7 | 14:21 | -7 | 15 |
| 17 |
|
Keçiörengücü | 14 | 4 | 2 | 8 | 16:22 | -6 | 14 |
| 18 |
|
Altınordu FK | 15 | 4 | 1 | 10 | 15:29 | -14 | 13 |
| 19 |
|
Balıkesirspor | 14 | 2 | 1 | 11 | 9:23 | -14 | 7 |
| Ascenso | |
| Playoff | |
| Descenso |
