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| 14.01.2022 | 18:00 | Menemen Belediyespor | - | Bandırmaspor | 1:1 (0:0) | |
| 15.01.2022 | 11:30 | Denizlispor | - | Manisa FK | 0:1 (0:1) | |
| 14:00 | İstanbulspor AŞ | - | Ümraniyespor | 1:0 (0:0) | ||
| 17:00 | Kocaelispor | - | MKE Ankaragücü | 1:2 (1:1) | ||
| 16.01.2022 | 11:30 | Keçiörengücü | - | Eyüpspor | 0:0 (0:0) | |
| 11:30 | Tuzlaspor | - | Altınordu FK | 2:1 (1:1) | ||
| 14:00 | Balıkesirspor | - | Samsunspor | 0:2 (0:1) | ||
| 17:00 | Bursaspor | - | BB Erzurumspor | 0:0 (0:0) | ||
| 17.01.2022 | 18:00 | Gençlerbirliği | - | Adanaspor | 0:3 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
MKE Ankaragücü | 20 | 13 | 3 | 4 | 32:15 | 17 | 42 |
| 2 |
|
Ümraniyespor | 20 | 13 | 3 | 4 | 35:16 | 19 | 42 |
| 3 |
|
BB Erzurumspor | 20 | 11 | 5 | 4 | 33:22 | 11 | 38 |
| 4 |
|
Eyüpspor | 20 | 10 | 6 | 4 | 30:22 | 8 | 36 |
| 5 |
|
Bandırmaspor | 20 | 10 | 3 | 7 | 32:20 | 12 | 33 |
| 6 |
|
İstanbulspor AŞ | 20 | 10 | 3 | 7 | 30:25 | 5 | 33 |
| 7 |
|
Adanaspor | 20 | 9 | 5 | 6 | 26:20 | 6 | 32 |
| 8 |
|
Samsunspor | 19 | 8 | 6 | 5 | 28:23 | 5 | 30 |
| 9 |
|
Tuzlaspor | 20 | 7 | 6 | 7 | 21:20 | 1 | 27 |
| 10 |
|
Gençlerbirliği | 20 | 8 | 2 | 10 | 23:29 | -6 | 26 |
| 11 |
|
Manisa FK | 20 | 7 | 4 | 9 | 22:26 | -4 | 25 |
| 12 |
|
Boluspor | 19 | 6 | 6 | 7 | 21:21 | 0 | 24 |
| 13 |
|
Kocaelispor | 20 | 7 | 3 | 10 | 20:25 | -5 | 24 |
| 14 |
|
Keçiörengücü | 20 | 6 | 5 | 9 | 27:32 | -5 | 23 |
| 15 |
|
Menemen Belediyespor | 20 | 5 | 8 | 7 | 23:33 | -10 | 23 |
| 16 |
|
Altınordu FK | 20 | 7 | 1 | 12 | 27:40 | -13 | 22 |
| 17 |
|
Bursaspor | 20 | 5 | 5 | 10 | 23:31 | -8 | 20 |
| 18 |
|
Denizlispor | 20 | 5 | 4 | 11 | 19:30 | -11 | 19 |
| 19 |
|
Balıkesirspor | 20 | 2 | 2 | 16 | 14:36 | -22 | 8 |
| Ascenso | |
| Playoff | |
| Descenso |
