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| 19.04.2022 | 12:30 | Ümraniyespor | - | Keçiörengücü | 2:1 (2:0) | |
| 15:00 | Denizlispor | - | İstanbulspor AŞ | 4:3 (2:3) | ||
| 17:00 | Bursaspor | - | Gençlerbirliği | 0:0 (0:0) | ||
| 20.04.2022 | 12:30 | Manisa FK | - | Balıkesirspor | 3:0 (0:0) | |
| 15:00 | MKE Ankaragücü | - | Altınordu FK | 2:3 (1:2) | ||
| 15:00 | BB Erzurumspor | - | Tuzlaspor | 1:1 (0:1) | ||
| 17:00 | Menemen Belediyespor | - | Kocaelispor | 1:1 (1:0) | ||
| 21.04.2022 | 16:00 | Adanaspor | - | Samsunspor | 1:0 (0:0) | |
| 19:30 | Eyüpspor | - | Boluspor | 0:2 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
MKE Ankaragücü | 32 | 19 | 6 | 7 | 51:28 | 23 | 63 |
| 2 |
|
Ümraniyespor | 31 | 18 | 6 | 7 | 52:31 | 21 | 60 |
| 3 |
|
Bandırmaspor | 31 | 17 | 4 | 10 | 47:27 | 20 | 55 |
| 4 |
|
İstanbulspor AŞ | 31 | 16 | 6 | 9 | 53:36 | 17 | 54 |
| 5 |
|
BB Erzurumspor | 31 | 14 | 9 | 8 | 49:35 | 14 | 51 |
| 6 |
|
Eyüpspor | 32 | 13 | 12 | 7 | 48:38 | 10 | 51 |
| 7 |
|
Manisa FK | 32 | 13 | 7 | 12 | 38:36 | 2 | 46 |
| 8 |
|
Adanaspor | 32 | 12 | 8 | 12 | 36:33 | 3 | 44 |
| 9 |
|
Samsunspor | 31 | 11 | 10 | 10 | 47:41 | 6 | 43 |
| 10 |
|
Tuzlaspor | 31 | 11 | 9 | 11 | 34:32 | 2 | 42 |
| 11 |
|
Altınordu FK | 32 | 13 | 2 | 17 | 39:55 | -16 | 41 |
| 12 |
|
Denizlispor | 31 | 11 | 6 | 14 | 38:47 | -9 | 39 |
| 13 |
|
Gençlerbirliği | 31 | 11 | 6 | 14 | 34:46 | -12 | 39 |
| 14 |
|
Boluspor | 31 | 10 | 8 | 13 | 34:38 | -4 | 38 |
| 15 |
|
Keçiörengücü | 31 | 10 | 8 | 13 | 37:42 | -5 | 38 |
| 16 |
|
Menemen Belediyespor | 31 | 8 | 13 | 10 | 39:49 | -10 | 37 |
| 17 |
|
Kocaelispor | 31 | 10 | 7 | 14 | 31:42 | -11 | 37 |
| 18 |
|
Bursaspor | 31 | 8 | 8 | 15 | 33:46 | -13 | 32 |
| 19 |
|
Balıkesirspor | 31 | 3 | 3 | 25 | 23:61 | -38 | 12 |
| Ascenso | |
| Playoff | |
| Descenso |
