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| 24.09.2021 | 19:00 | Altay Izmir | - | Beşiktaş | 2:1 (0:0) | |
| 25.09.2021 | 12:30 | Sivasspor | - | Fatih Karagümrük SK | 4:0 (1:0) | |
| 15:00 | Antalyaspor | - | Yeni Malatyaspor | 1:0 (0:0) | ||
| 18:00 | Adana Demirspor | - | Gaziantep FK | 4:0 (1:0) | ||
| 26.09.2021 | 12:30 | Giresunspor | - | Kayserispor | 1:1 (1:1) | |
| 15:00 | Hatayspor | - | Fenerbahçe | 1:2 (0:2) | ||
| 15:00 | İstanbul Başakşehir | - | Çaykur Rizespor | 3:0 (1:0) | ||
| 18:00 | Galatasaray | - | Göztepe | 2:1 (0:1) | ||
| 27.09.2021 | 19:00 | Kasımpaşa SK | - | Konyaspor | 2:2 (1:2) | |
| 19:00 | Trabzonspor | - | Alanyaspor | 1:1 (1:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Fenerbahçe | 7 | 5 | 1 | 1 | 10:5 | 5 | 16 |
| 2 |
|
Trabzonspor | 7 | 4 | 3 | 0 | 14:7 | 7 | 15 |
| 3 |
|
Altay Izmir | 7 | 5 | 0 | 2 | 14:9 | 5 | 15 |
| 4 |
|
Beşiktaş | 7 | 4 | 2 | 1 | 14:7 | 7 | 14 |
| 5 |
|
Hatayspor | 7 | 4 | 1 | 2 | 14:6 | 8 | 13 |
| 6 |
|
Konyaspor | 7 | 3 | 4 | 0 | 11:7 | 4 | 13 |
| 7 |
|
Alanyaspor | 7 | 4 | 1 | 2 | 7:10 | -3 | 13 |
| 8 |
|
Kayserispor | 7 | 3 | 2 | 2 | 9:7 | 2 | 11 |
| 9 |
|
Fatih Karagümrük SK | 7 | 3 | 2 | 2 | 11:10 | 1 | 11 |
| 10 |
|
Galatasaray | 7 | 3 | 2 | 2 | 10:10 | 0 | 11 |
| 11 |
|
Sivasspor | 7 | 2 | 3 | 2 | 10:7 | 3 | 9 |
| 12 |
|
Adana Demirspor | 7 | 2 | 3 | 2 | 12:11 | 1 | 9 |
| 13 |
|
Antalyaspor | 7 | 2 | 2 | 3 | 7:10 | -3 | 8 |
| 14 |
|
Gaziantep FK | 7 | 2 | 2 | 3 | 6:10 | -4 | 8 |
| 15 |
|
İstanbul Başakşehir | 7 | 2 | 0 | 5 | 7:7 | 0 | 6 |
| 16 |
|
Kasımpaşa SK | 7 | 1 | 3 | 3 | 7:10 | -3 | 6 |
| 17 |
|
Yeni Malatyaspor | 7 | 2 | 0 | 5 | 7:14 | -7 | 6 |
| 18 |
|
Göztepe | 7 | 1 | 2 | 4 | 7:11 | -4 | 5 |
| 19 |
|
Giresunspor | 7 | 0 | 2 | 5 | 2:9 | -7 | 2 |
| 20 |
|
Çaykur Rizespor | 7 | 0 | 1 | 6 | 4:16 | -12 | 1 |
| Champions League | |
| CL Ronda previa | |
| ECL Ronda previa | |
| Descenso |
