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| I | Seattle Sounders | - | Real Salt Lake | 0:0 (0:0) | ||
| V | Real Salt Lake | - | Seattle Sounders | 0:1 (0:0) | ||
| I: 03.11.2012 03:00 | V: 09.11.2012 04:00 | Campeones: Seattle Sounders | ||||
| I | D.C. United | - | New York RB | 1:1 (0:0) | ||
| V | New York RB | - | D.C. United | 0:1 (0:0) | ||
| I: 04.11.2012 01:00 | V: 09.11.2012 01:30 | Campeones: D.C. United | ||||
| I | Houston Dynamo | - | Sporting Kansas City | 2:0 (1:0) | ||
| V | Sporting Kansas City | - | Houston Dynamo | 1:0 (0:0) | ||
| I: 04.11.2012 21:30 | V: 08.11.2012 03:00 | Campeones: Houston Dynamo | ||||
| I | Los Angeles Galaxy | - | San Jose Earthquakes | 0:1 (0:0) | ||
| V | San Jose Earthquakes | - | Los Angeles Galaxy | 1:3 (0:3) | ||
| I: 05.11.2012 03:00 | V: 08.11.2012 05:00 | Campeones: Los Angeles Galaxy | ||||
