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| SL2 | 20.01.2021 | Xanthi FC | - | Ionikos Nikea | 1:0 | ??? |
| SL2 | 30.01.2021 | Xanthi FC | - | PAE Chania | 0:0 | ??? |
| SL2 | 13.02.2021 | Xanthi FC | - | AO Trikala | 1:0 | ??? |
| SL2 | 21.02.2021 | Xanthi FC | - | OFI Ierapetra | 2:1 | ??? |
| SL2 | 03.03.2021 | Xanthi FC | - | Apollon Lárissa | 0:0 | ??? |
| SL2 | 10.03.2021 | Xanthi FC | - | Doxa Dramas FC | 1:0 | ??? |
| SL2 | 17.03.2021 | Xanthi FC | - | Levadiakos | 1:0 | ??? |
| SL2 | 27.03.2021 | Xanthi FC | - | Ergotelis | 1:0 | ??? |
| SL2 | 03.04.2021 | Xanthi FC | - | AE Karaiskakis | 1:1 | ??? |
| SL2 | 11.04.2021 | Xanthi FC | - | Diagoras FC | 2:0 | ??? |
| SL2 | 21.04.2021 | Xanthi FC | - | Panachaiki GE | 4:0 | ??? |
| SL2 | 28.04.2021 | Xanthi FC | - | PAE Chania | 1:1 | ??? |
| SL2 | 16.05.2021 | Xanthi FC | - | Ergotelis | 0:1 | ??? |
| SL2 | 19.05.2021 | Xanthi FC | - | Levadiakos | 1:0 | ??? |
| Playoffs 1/2 | 26.05.2021 | Xanthi FC | - | Panetolikos | 2:1 | ??? |
| Kypello | 27.10.2021 | Xanthi FC | - | Ionikos Nikea | 1:2 | ??? |
| SL2 | 21.11.2021 | Xanthi FC | - | Thesprotos | 1:0 | ??? |
| SL2 | 28.11.2021 | Xanthi FC | - | Almopos Arideas | 2:0 | ??? |
| SL2 | 11.12.2021 | Xanthi FC | - | Olympiacos Volou | 2:0 | ??? |
| SL2 | 19.12.2021 | Xanthi FC | - | AO Trikala | 5:0 | ??? |
Grecia