| 1. Jornada | 01.08.2022 | Liverpool | - | Defensor Sporting | 1:3 |  |
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| 2. Jornada | 07.08.2022 | Defensor Sporting | - | Peñarol | 2:3 | |
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| 3. Jornada | 14.08.2022 | Montevideo City Torque | - | Defensor Sporting | 0:2 | ||||
| 6. Jornada | 21.08.2022 | Defensor Sporting | - | Boston River | 0:1 | ||||
| 5. Jornada | 28.08.2022 | Plaza Colonia | - | Defensor Sporting | 0:1 |  |
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| 4. Jornada | 03.09.2022 | Defensor Sporting | - | Montevideo Wanderers | 1:0 | ||||
| 7. Jornada | 11.09.2022 | River Plate | - | Defensor Sporting | 0:1 | |
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| 8. Jornada | 16.09.2022 | Defensor Sporting | - | Cerro Largo | 0:1 | ||||
| 9. Jornada | 20.09.2022 | Fénix | - | Defensor Sporting | 0:0 | ||||
| 10. Jornada | 26.09.2022 | Cerrito | - | Defensor Sporting | 1:2 | ||||
| 11. Jornada | 02.10.2022 | Defensor Sporting | - | Albion | 2:0 | ||||
| 12. Jornada | 09.10.2022 | Nacional | - | Defensor Sporting | 1:1 | |
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| 13. Jornada | 13.10.2022 | Defensor Sporting | - | Danubio | 1:1 | ||||
| 14. Jornada | 15.10.2022 | Deportivo Maldonado | - | Defensor Sporting | 0:0 | ||||
| 15. Jornada | 22.10.2022 | Defensor Sporting | - | Rentistas | 2:3 | |
Uruguay