| 1. Jornada | 08.01.2022 | Gallos Blancos [Sub 16] | - | CF América [Sub 16] | 0:3 | ||||
| 2. Jornada | 15.01.2022 | CF América [Sub 16] | - | Pumas UNAM [Sub 16] | 1:0 | ||||
| 4. Jornada | 29.01.2022 | CF Pachuca [Sub 16] | - | CF América [Sub 16] | 0:3 | ||||
| 3. Jornada | 09.02.2022 | CF América [Sub 16] | - | Puebla FC [Sub 16] | 1:0 |  |
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| 6. Jornada | 12.02.2022 | FC Juárez [Sub 16] | - | CF América [Sub 16] | 1:0 | |
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| 8. Jornada | 26.02.2022 | CF América [Sub 16] | - | Deportivo Toluca [Sub 16] | 0:4 |
México