| 4. Jornada | 21.02.2021 | Guaraní | - | Club Olimpia | 0:3 | ||||
| 5. Jornada | 28.02.2021 | Club Olimpia | - | Cerro Porteño | 2:0 |  |
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| 6. Jornada | 07.03.2021 | Sol de América | - | Club Olimpia | 0:2 | ||||
| 7. Jornada | 10.03.2021 | Club Olimpia | - | Club Nacional | 1:4 |  |
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| 8. Jornada | 15.03.2021 | Sportivo Luqueño | - | Club Olimpia | 4:2 | ||||
| 9. Jornada | 22.03.2021 | Club Olimpia | - | River Plate | 5:1 | |
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| 10. Jornada | 04.04.2021 | Libertad | - | Club Olimpia | 0:1 | ||||
| 11. Jornada | 11.04.2021 | Club Olimpia | - | 12 de Octubre de Itauguá | 2:2 | ||||
| 12. Jornada | 17.04.2021 | Guaireña FC | - | Club Olimpia | 1:2 | |
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| 13. Jornada | 25.04.2021 | Club Olimpia | - | Guaraní | 2:1 | |
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| 14. Jornada | 02.05.2021 | Cerro Porteño | - | Club Olimpia | 2:0 | |
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| 15. Jornada | 09.05.2021 | Club Olimpia | - | Sol de América | 3:3 | |
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| 16. Jornada | 18.05.2021 | Club Nacional | - | Club Olimpia | 2:1 | ||||
| 17. Jornada | 23.05.2021 | Club Olimpia | - | Sportivo Luqueño | 4:1 | |
Uruguay