| 2. Jornada | 19.02.2021 | Colón de Santa Fe II | - | San Lorenzo II | 1:1 | ||||
| 3. Jornada | 26.02.2021 | Banfield II | - | Colón de Santa Fe II | 0:0 | ||||
| 9. Jornada | 09.04.2021 | River Plate II | - | Colón de Santa Fe II | 7:0 | ||||
| 10. Jornada | 16.04.2021 | Colón de Santa Fe II | - | Godoy Cruz II | 1:2 | ||||
| 11. Jornada | 23.04.2021 | Racing Club II | - | Colón de Santa Fe II | 0:1 | ||||
| 12. Jornada | 30.04.2021 | Colón de Santa Fe II | - | Arsenal de Sarandí II | 2:0 | ||||
| 13. Jornada | 07.05.2021 | Colón de Santa Fe II | - | Unión de Santa Fe II | 0:1 |
Argentina