| 1. Jornada | 06.01.2022 | Atlético San Luis [Sub 18] | - | CF Pachuca [Sub 18] | 1:0 | ||||
| 2. Jornada | 16.01.2022 | CF Pachuca [Sub 18] | - | Deportivo Guadalajara [Sub 18] | 4:2 |  |
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| 3. Jornada | 22.01.2022 | Club León [Sub 18] | - | CF Pachuca [Sub 18] | 4:2 | ||||
| 4. Jornada | 05.02.2022 | Club Necaxa [Sub 18] | - | CF Pachuca [Sub 18] | 0:1 | |
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| 5. Jornada | 14.02.2022 | CF Pachuca [Sub 18] | - | Gallos Blancos [Sub 18] | 0:1 | ||||
| 6. Jornada | 20.02.2022 | CF América [Sub 18] | - | CF Pachuca [Sub 18] | 3:0 | ||||
| 11. Jornada | 19.03.2022 | CF Pachuca [Sub 18] | - | Cruz Azul [Sub 18] | 3:2 | ||||
| 9. Jornada | 23.03.2022 | CF Pachuca [Sub 18] | - | UANL Tigres [Sub 18] | 4:0 | ||||
| 13. Jornada | 11.04.2022 | CF Pachuca [Sub 18] | - | Club Tijuana [Sub 18] | 1:2 | ||||
| 14. Jornada | 15.04.2022 | FC Juárez [Sub 18] | - | CF Pachuca [Sub 18] | 2:0 | ||||
| 15. Jornada | 19.04.2022 | CF Pachuca [Sub 18] | - | Puebla FC [Sub 18] | 3:0 |
México