| 1. Jornada | 13.08.2011 | Defensor Sporting | - | Rampla Juniors | 2:0 |  |
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| 2. Jornada | 20.08.2011 | Nacional | - | Defensor Sporting | 2:2 | ||||
| 3. Jornada | 28.08.2011 | Defensor Sporting | - | Cerrito | 1:1 | ||||
| 4. Jornada | 03.09.2011 | Peñarol | - | Defensor Sporting | 1:0 | ||||
| 5. Jornada | 11.09.2011 | Defensor Sporting | - | Fénix | 0:1 | ||||
| 6. Jornada | 18.09.2011 | Liverpool | - | Defensor Sporting | 2:3 | |
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| 7. Jornada | 24.09.2011 | Defensor Sporting | - | Rentistas | 1:0 | |
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| 8. Jornada | 02.10.2011 | Racing | - | Defensor Sporting | 0:3 | |
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| 9. Jornada | 09.10.2011 | Defensor Sporting | - | CA Cerro | 2:3 | |
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| 11. Jornada | 04.11.2011 | Defensor Sporting | - | Danubio | 0:1 | |
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| 10. Jornada | 08.11.2011 | Montevideo Wanderers | - | Defensor Sporting | 0:2 | ||||
| 12. Jornada | 13.11.2011 | Cerro Largo | - | Defensor Sporting | 0:3 | ||||
| 13. Jornada | 19.11.2011 | Defensor Sporting | - | Bella Vista | 2:1 | ||||
| 14. Jornada | 27.11.2011 | El Tanque Sisley | - | Defensor Sporting | 2:2 | ||||
| 15. Jornada | 02.12.2011 | Defensor Sporting | - | River Plate | 0:2 |
Uruguay