| 1. Jornada | 12.09.2021 | Boston River | - | Montevideo Wanderers | 1:3 |  |
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| 2. Jornada | 20.09.2021 | Deportivo Maldonado | - | Montevideo Wanderers | 1:3 | ||||
| 3. Jornada | 26.09.2021 | Montevideo Wanderers | - | Rentistas | 2:1 | |
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| 4. Jornada | 04.10.2021 | Peñarol | - | Montevideo Wanderers | 3:0 | ||||
| 5. Jornada | 09.10.2021 | Montevideo Wanderers | - | Montevideo City Torque | 0:1 | ||||
| 6. Jornada | 17.10.2021 | Villa Española | - | Montevideo Wanderers | 2:2 | ||||
| 7. Jornada | 22.10.2021 | Montevideo Wanderers | - | Nacional | 1:0 | ||||
| 8. Jornada | 24.10.2021 | Cerrito | - | Montevideo Wanderers | 2:2 | ||||
| 9. Jornada | 30.10.2021 | Montevideo Wanderers | - | Liverpool | 1:0 | ||||
| 10. Jornada | 03.11.2021 | River Plate | - | Montevideo Wanderers | 0:1 | ||||
| 11. Jornada | 08.11.2021 | Montevideo Wanderers | - | Cerro Largo | 1:2 | ||||
| 12. Jornada | 15.11.2021 | Progreso | - | Montevideo Wanderers | 3:1 | ||||
| 13. Jornada | 19.11.2021 | Montevideo Wanderers | - | Sud América | 4:1 | ||||
| 14. Jornada | 26.11.2021 | Plaza Colonia | - | Montevideo Wanderers | 0:1 | |
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| 15. Jornada | 04.12.2021 | Montevideo Wanderers | - | Fénix | 1:1 | |
Uruguay