| 2. Jornada | 12.02.2022 | Jorge Wilstermann | - | Blooming | 0:1 |  |
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| 3. Jornada | 20.02.2022 | Royal Pari | - | Blooming | 1:1 | ||||
| 6. Jornada | 13.03.2022 | Oriente Petrolero | - | Blooming | 1:2 | ||||
| 7. Jornada | 02.04.2022 | Blooming | - | Always Ready | 1:0 | ||||
| 8. Jornada | 10.04.2022 | Real Tomayapo | - | Blooming | 1:2 | ||||
| 9. Jornada | 16.04.2022 | Bolívar | - | Blooming | 6:0 | ||||
| 10. Jornada | 20.04.2022 | Blooming | - | Jorge Wilstermann | 3:3 |  |
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| 11. Jornada | 25.04.2022 | Blooming | - | Royal Pari | 1:1 | ||||
| 12. Jornada | 01.05.2022 | Universitario de Vinto | - | Blooming | 2:1 | ||||
| 13. Jornada | 09.05.2022 | Blooming | - | Oriente Petrolero | 1:2 | ||||
| 14. Jornada | 13.05.2022 | Blooming | - | Independiente Petrolero | 4:0 | |
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| 15. Jornada | 15.05.2022 | Always Ready | - | Blooming | 3:0 | |
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| 16. Jornada | 22.05.2022 | Blooming | - | Real Tomayapo | 2:1 |
Bolivia