| 1. Jornada | 06.02.2022 | Boston River | - | Plaza Colonia | 0:0 | ||||
| 2. Jornada | 12.02.2022 | Plaza Colonia | - | River Plate | 0:1 | ||||
| 3. Jornada | 19.02.2022 | Cerro Largo | - | Plaza Colonia | 0:5 |  |
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| 4. Jornada | 25.02.2022 | Plaza Colonia | - | Fénix | 1:1 | |
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| 5. Jornada | 12.03.2022 | Defensor Sporting | - | Plaza Colonia | 0:0 | ||||
| 6. Jornada | 20.03.2022 | Plaza Colonia | - | Albion | 1:1 | ||||
| 7. Jornada | 02.04.2022 | Nacional | - | Plaza Colonia | 1:0 | ||||
| 8. Jornada | 09.04.2022 | Plaza Colonia | - | Danubio | 1:1 | |
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| 9. Jornada | 17.04.2022 | Deportivo Maldonado | - | Plaza Colonia | 3:1 | ||||
| 10. Jornada | 25.04.2022 | Plaza Colonia | - | Rentistas | 0:3 | |
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| 11. Jornada | 07.05.2022 | Liverpool | - | Plaza Colonia | 1:0 | ||||
| 12. Jornada | 14.05.2022 | Plaza Colonia | - | Peñarol | 0:1 | ||||
| 13. Jornada | 24.05.2022 | Montevideo City Torque | - | Plaza Colonia | 1:1 | |
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| 14. Jornada | 29.05.2022 | Plaza Colonia | - | Montevideo Wanderers | 1:0 | |
Brasil