| 1. Jornada | 06.02.2022 | Guaireña FC | - | Guaraní | 0:0 |  |
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| 2. Jornada | 12.02.2022 | Guaireña FC | - | Club Olimpia | 1:3 | ||||
| 3. Jornada | 20.02.2022 | Sol de América | - | Guaireña FC | 1:0 | ||||
| 4. Jornada | 27.02.2022 | Guaireña FC | - | Cerro Porteño | 0:2 | |
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| 5. Jornada | 05.03.2022 | Resistencia SC | - | Guaireña FC | 2:2 | ||||
| 6. Jornada | 14.03.2022 | Guaireña FC | - | 12 de Octubre de Itauguá | 0:0 | ||||
| 7. Jornada | 22.03.2022 | General Caballero DJLM | - | Guaireña FC | 0:1 |  |
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| 8. Jornada | 03.04.2022 | Guaireña FC | - | Libertad | 2:3 | ||||
| 9. Jornada | 11.04.2022 | Tacuary | - | Guaireña FC | 0:1 | ||||
| 10. Jornada | 17.04.2022 | Guaireña FC | - | Sportivo Ameliano | 2:1 | |
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| 11. Jornada | 21.04.2022 | Club Nacional | - | Guaireña FC | 3:1 | |
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| 12. Jornada | 25.04.2022 | Guaraní | - | Guaireña FC | 2:1 | |
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| 15. Jornada | 12.05.2022 | Cerro Porteño | - | Guaireña FC | 0:0 | ||||
| 16. Jornada | 14.05.2022 | Guaireña FC | - | Resistencia SC | 0:0 | |
Paraguay