| 4. Jornada | 14.08.2021 | Club León [Sub 20] | - | Mazatlán FC [Sub 20] | 1:0 | ||||
| 5. Jornada | 18.08.2021 | Deportivo Guadalajara [Sub 20] | - | Club León [Sub 20] | 1:2 | ||||
| 6. Jornada | 21.08.2021 | Club León [Sub 20] | - | Santos Laguna [Sub 20] | 1:1 | ||||
| 8. Jornada | 11.09.2021 | UANL Tigres [Sub 20] | - | Club León [Sub 20] | 2:0 | ||||
| 9. Jornada | 18.09.2021 | Club León [Sub 20] | - | FC Juárez [Sub 20] | 2:0 | ||||
| 11. Jornada | 03.11.2021 | Cruz Azul [Sub 20] | - | Club León [Sub 20] | 2:0 |  |
México