| 6. Jornada | 21.08.2021 | Club León [Sub 20] | - | Santos Laguna [Sub 20] | 1:1 | ||||
| 9. Jornada | 19.09.2021 | Santos Laguna [Sub 20] | - | Puebla FC [Sub 20] | 4:2 | ||||
| 10. Jornada | 26.09.2021 | Santos Laguna [Sub 20] | - | CF Monterrey [Sub 20] | 4:1 |  |
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| 12. Jornada | 02.10.2021 | Santos Laguna [Sub 20] | - | Mazatlán FC [Sub 20] | 4:2 | ||||
| 13. Jornada | 16.10.2021 | CF Pachuca [Sub 20] | - | Santos Laguna [Sub 20] | 2:2 | ||||
| 15. Jornada | 24.10.2021 | Santos Laguna [Sub 20] | - | Deportivo Toluca [Sub 20] | 3:0 | ||||
| 16. Jornada | 30.10.2021 | Gallos Blancos [Sub 20] | - | Santos Laguna [Sub 20] | 0:5 | ||||
| 17. Jornada | 07.11.2021 | Santos Laguna [Sub 20] | - | Atlético San Luis [Sub 20] | 2:1 |
México