| 1. Jornada | 06.01.2019 | Lobos BUAP | - | Santos Laguna | 2:0 | ||||
| 2. Jornada | 14.01.2019 | Santos Laguna | - | Monarcas Morelia | 1:0 | ||||
| 3. Jornada | 19.01.2019 | Puebla FC | - | Santos Laguna | 1:1 | ||||
| 5. Jornada | 03.02.2019 | UANL Tigres | - | Santos Laguna | 2:1 | ||||
| 6. Jornada | 11.02.2019 | Santos Laguna | - | Club Tijuana | 1:1 | ||||
| 7. Jornada | 17.02.2019 | Cruz Azul | - | Santos Laguna | 1:2 |  |
|||
| 8. Jornada | 25.02.2019 | Santos Laguna | - | Deportivo Toluca | 4:0 | |
|||
| 13. Jornada | 08.04.2019 | Santos Laguna | - | CF Pachuca | 0:0 |  |
|||
| 17. Jornada | 06.05.2019 | Santos Laguna | - | Pumas UNAM | 5:2 |
Ecuador
España 
