| 5. Jornada | 06.08.2021 | Sarmiento de Junín II | - | Rosario Central II | 2:2 |  |
|||
| 6. Jornada | 13.08.2021 | Rosario Central II | - | Independiente II | 3:1 | |
|||
| 9. Jornada | 30.08.2021 | Central Córdoba SdE II | - | Rosario Central II | 0:1 | ||||
| 11. Jornada | 14.09.2021 | Banfield II | - | Rosario Central II | 1:3 | ||||
| 13. Jornada | 24.09.2021 | Talleres de Córdoba II | - | Rosario Central II | 3:1 | ||||
| 14. Jornada | 01.10.2021 | Rosario Central II | - | Argentinos Juniors II | 0:2 | ||||
| 16. Jornada | 13.10.2021 | Rosario Central II | - | Patronato de Paraná II | 2:1 | ||||
| 17. Jornada | 18.10.2021 | Platense II | - | Rosario Central II | 0:3 | ||||
| 19. Jornada | 29.10.2021 | Unión de Santa Fe II | - | Rosario Central II | 0:0 | ||||
| 22. Jornada | 24.11.2021 | Colón de Santa Fe II | - | Rosario Central II | 1:1 |
Argentina