| Grupo B | 14.06.2022 | Defensor Sporting | - | Nacional | 0:1 | ||||
| Grupo B | 20.06.2022 | Cerrito | - | Defensor Sporting | 1:2 | ||||
| Grupo B | 10.07.2022 | Boston River | - | Defensor Sporting | 2:3 | ||||
| Grupo B | 17.07.2022 | Defensor Sporting | - | Danubio | 2:1 | ||||
| Grupo B | 21.07.2022 | River Plate | - | Defensor Sporting | 1:1 | ||||
| Grupo B | 24.07.2022 | Defensor Sporting | - | Plaza Colonia | 1:2 |  |
Uruguay