| 4. Jornada | 02.08.2021 | Atlético Tucumán II | - | Vélez Sarsfield II | 3:0 |  |
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| 5. Jornada | 06.08.2021 | Gimnasia de La Plata II | - | Atlético Tucumán II | 1:0 | ||||
| 8. Jornada | 24.08.2021 | Atlético Tucumán II | - | Independiente II | 0:0 | ||||
| 9. Jornada | 30.08.2021 | Newell's Old Boys II | - | Atlético Tucumán II | 2:3 | |
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| 10. Jornada | 04.09.2021 | Atlético Tucumán II | - | Arsenal de Sarandí II | 0:1 | ||||
| 11. Jornada | 10.09.2021 | Central Córdoba SdE II | - | Atlético Tucumán II | 1:1 | |
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| 12. Jornada | 18.09.2021 | Atlético Tucumán II | - | Boca Juniors II | 1:1 | |
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| 13. Jornada | 24.09.2021 | Banfield II | - | Atlético Tucumán II | 1:0 | ||||
| 15. Jornada | 08.10.2021 | Talleres de Córdoba II | - | Atlético Tucumán II | 1:1 | ||||
| 17. Jornada | 20.10.2021 | Estudiantes II | - | Atlético Tucumán II | 0:2 | |
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| 18. Jornada | 25.10.2021 | Atlético Tucumán II | - | Patronato de Paraná II | 0:1 | ||||
| 19. Jornada | 29.10.2021 | Platense II | - | Atlético Tucumán II | 0:1 | ||||
| 20. Jornada | 05.11.2021 | Atlético Tucumán II | - | Racing Club II | 2:1 | ||||
| 21. Jornada | 20.11.2021 | Rosario Central II | - | Atlético Tucumán II | 4:1 | |
Argentina