| 1. Jornada | 08.01.2018 | Santos Laguna | - | Lobos BUAP | 4:2 | ||||
| 2. Jornada | 14.01.2018 | UANL Tigres | - | Santos Laguna | 2:1 | ||||
| 3. Jornada | 22.01.2018 | Santos Laguna | - | Monarcas Morelia | 1:0 | ||||
| 10. Jornada | 04.03.2018 | Club Necaxa | - | Santos Laguna | 1:2 | ||||
| 11. Jornada | 12.03.2018 | Santos Laguna | - | CF Monterrey | 3:2 | ||||
| 12. Jornada | 17.03.2018 | Puebla FC | - | Santos Laguna | 0:1 | ||||
| 13. Jornada | 31.03.2018 | Atlas Guadalajara | - | Santos Laguna | 3:2 | ||||
| 14. Jornada | 09.04.2018 | Santos Laguna | - | Gallos Blancos | 3:0 | ||||
| 15. Jornada | 15.04.2018 | CF Pachuca | - | Santos Laguna | 3:1 |  |
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| 16. Jornada | 23.04.2018 | Santos Laguna | - | Pumas UNAM | 1:2 | ||||
| 17. Jornada | 29.04.2018 | CF América | - | Santos Laguna | 1:0 |
Uruguay
España 
