| 5. Jornada | 07.08.2021 | Sarmiento de Junín | - | Rosario Central | 1:0 |  |
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| 6. Jornada | 15.08.2021 | Rosario Central | - | Independiente | 1:2 | ||||
| 8. Jornada | 25.08.2021 | Rosario Central | - | Arsenal de Sarandí | 4:0 | ||||
| 13. Jornada | 25.09.2021 | Talleres de Córdoba | - | Rosario Central | 4:1 | ||||
| 14. Jornada | 03.10.2021 | Rosario Central | - | Argentinos Juniors | 0:1 | ||||
| 15. Jornada | 09.10.2021 | Estudiantes | - | Rosario Central | 2:2 |  |
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| 16. Jornada | 15.10.2021 | Rosario Central | - | Patronato de Paraná | 3:2 | ||||
| 17. Jornada | 19.10.2021 | Platense | - | Rosario Central | 1:1 | ||||
| 18. Jornada | 24.10.2021 | Rosario Central | - | Racing Club | 2:1 | |
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| 19. Jornada | 31.10.2021 | Unión de Santa Fe | - | Rosario Central | 3:1 | |
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| 21. Jornada | 20.11.2021 | Rosario Central | - | Atlético Tucumán | 3:1 | |
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| 22. Jornada | 25.11.2021 | Colón de Santa Fe | - | Rosario Central | 1:4 | ||||
| 23. Jornada | 28.11.2021 | Rosario Central | - | River Plate | 2:2 | ||||
| 24. Jornada | 05.12.2021 | CA Lanús | - | Rosario Central | 2:2 | |
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| 25. Jornada | 11.12.2021 | Rosario Central | - | Huracán | 1:4 |
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