| 1. Jornada | 09.01.2022 | CF Monterrey | - | Gallos Blancos | 0:0 | ||||
| 2. Jornada | 15.01.2022 | Club Necaxa | - | CF Monterrey | 0:4 | ||||
| 3. Jornada | 23.01.2022 | CF Monterrey | - | Cruz Azul | 2:2 |  |
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| 6. Jornada | 19.02.2022 | Puebla FC | - | CF Monterrey | 1:0 | ||||
| 7. Jornada | 27.02.2022 | CF Monterrey | - | Atlético San Luis | 0:2 | ||||
| 9. Jornada | 06.03.2022 | CF Monterrey | - | CF América | 2:1 | ||||
| 5. Jornada | 16.03.2022 | CF Monterrey | - | FC Juárez | 3:0 | |
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| 4. Jornada | 07.04.2022 | Deportivo Toluca | - | CF Monterrey | 2:2 | ||||
| 13. Jornada | 10.04.2022 | CF Monterrey | - | Santos Laguna | 1:0 | ||||
| 12. Jornada | 14.04.2022 | Deportivo Guadalajara | - | CF Monterrey | 1:3 | ||||
| 14. Jornada | 17.04.2022 | Pumas UNAM | - | CF Monterrey | 2:0 | ||||
| 16. Jornada | 24.04.2022 | CF Pachuca | - | CF Monterrey | 3:0 |
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